Inhibitors of Protein-Protein Interaction Database







Coming soon :

  • new PPI families
  • addition of stabilizers of protein-protein interaction
  • 1756 non-peptide inhibitors
  • 2591 binding data
  • 18 families of Protein-Protein Interactions
  • 36 PPI targets


  • Search all iPPI-DB by chemical similarity
  • Search drug candidates for a given PPI target
  • Export your results as csv file
  • Addition of different names for the compound and the development phase according to MDDR if there's one in the summary tab of the ID card along with their ChEMBL ID
  • 1650 non-peptide inhibitors
  • 2461 binding data

Second release


 iPPI-DB: an online database of modulators of protein-protein interactions.

Labbé, C.M.; Kuenemann, M.A.; Zarzycka, B.; Vriend, G; Nicolaes, G.A.; Lagorce, D.; Miteva, M.A.; Villoutreix, B.O.; Sperandio O.

Nucleic Acids Research 2015, Epub ahead of print



  • Search by pharmacological criteria on a given target
  • ID card for each compound (summary, physichochemical and pharmacological data and similarity with drugs from MDDR march 2012)
  • Representative subset of 352 inhibitors
  • 13 families of Protein-Protein Interactions
  • 554 binding data

First release


 iPPI-DB: a manually curated and interactive database of small non-peptide inhibitors of protein-protein interactions.

Labbé, C.M.; Laconde, G.; Kuenemann, M.A.; Villoutreix, B.O.; Sperandio, O.

Drug Discovery Today 2013,18,958-968